The Role of Gangliosides in Neurodevelopment

Detection of Autoantibodies against Gangliosides in Guillain-Barré Syndrome

Persian surveys and questionnaires for neurodevelopmental assessment in children

Introduction: Cohort studies are defined as studies that investigate the correlation between exposures and diseases. Meanwhile, studies that investigate the effect of different exposures on children are of high priority, especially those focused on neurodevelopment. This study aimed to introduce available surveys in Persian language suitable for cohort studies that could be used for assessing n...

Dietary Sialyllactose Influences Sialic Acid Concentrations in the Prefrontal Cortex and Magnetic Resonance Imaging Measures in Corpus Callosum of Young Pigs

Sialic acid (SA) is a key component of gangliosides and neural cell adhesion molecules important during neurodevelopment. Human milk contains SA in the form of sialyllactose (SL) an abundant oligosaccharide. To better understand the potential role of dietary SL on neurodevelopment, the effects of varying doses of dietary SL on brain SA content and neuroimaging markers of development were assess...

Influence of dietary gangliosides on neonatal brain development.

Gangliosides are sialic acid-containing glycosphingolipids. Gangliosides are found in human milk; understanding of the potential role of gangliosides in infant development is emerging, with suggested roles in the brain and gut. Ganglioside accretion in the developing brain is highest in utero and in early neonatal life, during the periods of dendritic branching and new synapse formation. Furthe...

Lack of specificity of brain gangliosides in the modulation of lymphocyte activation.

A potential role for glycolipid gangliosides to act as immunomodulating agents has been suggested. Most studies have employed brain gangliosides. We have systematically investigated highly purified murine brain gangliosides for their ability to modulate lymphocyte activation. All sialic acid classes of ganglioside inhibited lipopolysaccharide (LPS)-induced antibody secretion and all polysialate...